869966-29-0Relevant academic research and scientific papers
Nucleophilic gem-difluoro(phenylsulfanyl)methylation of carbonyl compounds with PhSCF2H in the presence of a phosphazene as a base
Punirun, Teerachai,Soorukram, Darunee,Kuhakarn, Chutima,Reutrakul, Vichai,Pohmakotr, Manat
, p. 4162 - 4169 (2014)
Direct nucleophilic gem-difluoro(phenylsulfanyl)methylation of carbonyl compounds has been achieved by use of difluoro(phenylsulfanyl)methane (PhSCF2H) and the phosphazene base P4-tBu in THF. Non-enolizable aldehydes and ketones are suitable substrates to undergo nucleophilic gem-difluoro(phenylsulfanyl)methylation, providing α-gem-difluoromethylated adducts in good yields. In addition, this methodology is also applicable with cyclic imides and acid anhydrides. Direct nucleophilic gem-difluoro(phenylsulfanyl)methylation of aromatic aldehydes and ketones, cyclic imides, and acid anhydrides with difluoro(phenylsulfanyl)methane (PhSCF2H) reagent was achieved in the presence of the phosphazene P4-tBu as a base. The corresponding adducts should be useful for further synthetic conversion into a variety of fluorinated compounds. Copyright
