869968-28-5Relevant articles and documents
Discovery and SAR of cyclic isothioureas as novel NPY Y1 receptor antagonists
Sun, Zhong-Yue,Zhu, Zhaoning,Ye, Yuanzan,McKittrick, Brian,Czarniecki, Michael,Greenlee, William,Mullins, Deborra,Guzzi, Mario
, p. 6801 - 6805 (2009)
A class of novel 2-aminobenzothiazoles have been identified as NPY Y1 antagonists. Various N-heterocyclic substituted aminophenethyl-2-aminobenzothiazole analogs were synthesized to explore the SAR. Isothiourea analogs and ligands with high potency (Ki 30 nM) have been identified.
