86998-39-2

Upstream product

• 86998-36-9 C₄₃H₄₇NO₈S₂Si 
• 86998-45-0 (R)-2-[(2R,3S)-3-((R)-1-Benzyloxycarbonyloxy-ethyl)-2-(2-methoxycarbonyl-ethanesulfinyl)-4-oxo-azetidin-1-yl]-3-methyl-but-3-enoic acid benzyl ester 
• 86998-33-6 (2S,5R,6S)-6-((R)-1-Benzyloxycarbonyloxy-ethyl)-3,3-dimethyl-4,7-dioxo-4λ⁴-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzyl ester 

Downstream Products

• 86998-42-7 2-{(2R,3S)-3-((R)-1-Benzyloxycarbonyloxy-ethyl)-2-[2-(tert-butyl-diphenyl-silanyloxy)-acetylsulfanyl]-4-oxo-azetidin-1-yl}-3-methyl-but-2-enoic acid benzyl ester 

Relevant academic research and scientific papers

Desulphurative approaches to penem antibiotics. I. 4-acyldithioazetidin-2-ones via thermolysis of penicillin-derived sulphoxides

Thermolysis of penicillin-derived sulphoxides in the presence of thioacids offers a simple route to 4-acyldithioazetidin-2-ones, whose desulphurisation yields key intermediates for the synthesis of penem antibiotics.