869997-75-1

Upstream product

• 3054-95-3 acrylaldehyde diethyl acetal 
• 6630-33-7 ortho-bromobenzaldehyde 

Downstream Products

• 869997-78-4 (E)-3-[2-((E)-3-Naphthalen-2-yl-3-oxo-propenyl)-phenyl]-propenal 
• 869997-83-1 2-[2-((E)-3-Oxo-propenyl)-benzylidene]-malonic acid diethyl ester 
• 869997-79-5 (E)-3-{2-[(E)-3-(5-Bromo-thiophen-2-yl)-3-oxo-propenyl]-phenyl}-propenal 
• 869997-77-3 (E)-3-(2-((E)-3-oxo-3-phenylprop-1-enyl)phenyl)acrylaldehyde 
• 869997-80-8 (E)-3-(2-((E)-3-oxobut-1-enyl)phenyl)acrylaldehyde 
• 869997-76-2 (E)-3-[2-((E)-3,3-Diethoxy-propenyl)-phenyl]-1-phenyl-propenone 
• 61650-52-0 (E)-2-(3-oxoprop-1-enyl)benzaldehyde 

Relevant academic research and scientific papers

An efficient palladium-catalyzed synthesis of cinnamaldehydes from acrolein diethyl acetal and aryl iodides and bromides

(Matrix presented) The reaction of aryl iodides and bromides with acrolein diethyl acetal in the presence of Pd(OAc)2, nBu 4NOAc, K2CO3, KCl, and DMF, at 90°C until the disappearance of the acetal followed by the addition of 2 N HCl to the crude reaction mixture, affords cinnamaldehydes in good to high yields. A variety of functional groups are tolerated in the aryl halides, including ether, aldehyde, ketone, ester, dialkylamino, nitrile, and nitro groups. The presence of substituents close to the oxidative addition site does not hamper the reaction.

Synthesis of Benzothiophene-Fused Oxa[6.6.5]tricyclic Skeletons through a Cinchonidine- or NaOH-Promoted Quadruple Domino Sequence

Two base-promoted quadruple domino reactions between thioaurones and allylic phosphonium salts have been developed to synthesize benzothiophene-fused oxa[6.6.5]tricyclic skeletons in moderate to good yields with excellent stereoselectivity and broad functional-group tolerance. This is a simple and useful protocol for the rapid construction of the umbrella-like oxa[6.6.5]tricyclic skeleton.

Organocatalytic regiospecific synthesis of 1H-indene-2-carbaldehyde derivatives: suppression of cycloolefin isomerisation by employing sterically demanding catalysts

The regiospecific synthesis of 1H-indene-2-carbaldehyde derivatives was achieved through transition-metal-free, reductive cyclisation of ortho-formyl trans-cinnamaldehydes with Hantzsch ester in the presence of an aminocatalyst. In particular, cycloolefin isomerisation of the resulting products could be inhibited efficiently by the introduction of a sterically demanding stereo-defined aminocatalyst.

Catalytic asymmetric reductive Michael cyclization

A highly efficient and chemo-, regio-, diastereo-, and enantioselective organocatalytic tandem conjugate reduction-Michael cyclization of enal enones has been developed. Accordingly, treating the enal enone with a Hantzsch dihydropyridine in the presence