869998-49-2 Usage
Uses
Used in Neurological Applications:
SPD-304 is used as a neuroprotective agent for dorsal root ganglion neurons, where it inhibits the activity of tumor necrosis factor receptor 1 (TNFR1). This application is crucial for managing neuronal inflammation and potentially preventing neuronal damage.
Used in Gastrointestinal Applications:
In the field of gastrointestinal health, SPD-304 is used as an anti-inflammatory agent for colonic epithelial cell lines. It targets the inhibition of tumor necrosis factor alpha, which plays a significant role in reducing inflammation and promoting the healing of the colonic epithelium. This application can be beneficial in treating inflammatory bowel diseases and other gastrointestinal disorders.
Biochem/physiol Actions
SPD304 is a small molecule inhibitor of TNF-a activity with a novel mechanism of action. It interferes with protein-protein interactions on the contact surfaces of the trimeric TNF-a subunits, displacing one of the trimer units, resulting in dissociation of the trimer and loss of activity at the receptor TNFR1. SPD304 inhibits TNFR1 receptor binding to TNF-a with an IC50 of 22μM in vitro and inhibits TNF-a-mediated stimulation of IkB degradation in HeLa cells with an IC50 of 4.6 μM.
Check Digit Verification of cas no
The CAS Registry Mumber 869998-49-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,6,9,9,9 and 8 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 869998-49:
(8*8)+(7*6)+(6*9)+(5*9)+(4*9)+(3*8)+(2*4)+(1*9)=282
282 % 10 = 2
So 869998-49-2 is a valid CAS Registry Number.
