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870065-11-5

(S)-2-methyl-8-amino-4H-benzo[1,4]oxazin-3-one is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 870065-11-5 Structure

  • Basic information

    1. Product Name: (S)-2-methyl-8-amino-4H-benzo[1,4]oxazin-3-one
    2. Synonyms:
    3. CAS NO:870065-11-5
    4. Molecular Formula:
    5. Molecular Weight: 178.191
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 870065-11-5.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (S)-2-methyl-8-amino-4H-benzo[1,4]oxazin-3-one(CAS DataBase Reference)
    10. NIST Chemistry Reference: (S)-2-methyl-8-amino-4H-benzo[1,4]oxazin-3-one(870065-11-5)
    11. EPA Substance Registry System: (S)-2-methyl-8-amino-4H-benzo[1,4]oxazin-3-one(870065-11-5)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 870065-11-5(Hazardous Substances Data)

870065-11-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 870065-11-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,0,0,6 and 5 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 870065-11:
(8*8)+(7*7)+(6*0)+(5*0)+(4*6)+(3*5)+(2*1)+(1*1)=155
155 % 10 = 5
So 870065-11-5 is a valid CAS Registry Number.

870065-11-5Downstream Products

870065-11-5Relevant articles and documents

Synthesis, structure-activity relationships, and biological properties of 1-heteroaryl-4-[ω-(1H-indol-3-yl)alkyl]piperazines, novel potential antipsychotics combining potent dopamine D2 receptor antagonism with potent serotonin reuptake inhibition

Smid, Pieter,Coolen, Hein K. A. C.,Keizer, Hiskias G.,Van Hes, Rolf,De Moes, Jan-Peter,Den Hartog, Arnold P.,Stork, Bob,Plekkenpol, Rob H.,Niemann, Leonarda C.,Stroomer, Cees N. J.,Tulp, Martin Th. M.,Van Stuivenberg, Herman H.,McCreary, Andrew C.,Hesselink, Mayke B.,Herremans, Arnoud H. J.,Kruse, Chris G.

, p. 6855 - 6869 (2005)

A series of novel bicyclic 1-heteroaryl-4-[ω-(1H-indol-3-yl)alkyl] piperazines was synthesized and evaluated on binding to dopamine D2 receptors and serotonin reuptake sites. This class of compounds proved to be potent in vitro dopamine D2 receptor antagonists and in addition were highly active as serotonin reuptake inhibitors. Some key representatives showed potent pharmacological in vivo activities after oral dosing in both the antagonism of apomorphine-induced climbing and the potentiation of 5-HTP-induced behavior in mice. On the basis of the preclinical data, 8-{4-[3-(5-fluoro-1H- indol-3-yl)propyl]piperazin-1-yl}-4H-benzo[1,4]oxazin-(R)-2-methyl-3-one (45c, SLV314) was selected for clinical development. In vitro and in vivo studies revealed that 45c has favorable pharmacokinetic properties and a high CNS plasma ratio. Molecular modeling studies showed that the bifunctional activity of 45c can be explained by its ability to adopt two different conformations fitting either the dopamine D2 receptor pharmacophore or the serotonin transporter pharmacophore.

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