870065-92-2Relevant academic research and scientific papers
IMINOTHIADIAZINANE DIOXIDE DERIVATIVES AS PLASMEPSIN V INHIBITORS
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Page/Page column 30; 31, (2017/09/15)
A series of 3-imino-5-methyl-1,2,4-thiadiazinane 1,1-dioxide derivatives of formula (I), substituted in the 5-position by a phenyl moiety which in turn is meta-substituted by an optionally substituted fused bicyclic heteroaromatic ring system containing a
Trifluoromethylphenyl as P2 for ketoamide-based cathepsin S inhibitors
Cai, Jiaqiang,Robinson, John,Belshaw, Simone,Everett, Kathryn,Fradera, Xavier,Van Zeeland, Mario,Van Berkom, Leon,Van Rijnsbergen, Peter,Popplestone, Lucy,Baugh, Mark,Dempster, Maureen,Bruin, John,Hamilton, William,Kinghorn, Emma,Westwood, Paul,Kerr, Jennifer,Rankovic, Zoran,Arbuckle, Wullie,Bennett, D. Jonathan,Jones, Philip S.,Long, Clive,Martin, Iain,Uitdehaag, Joost C.M.,Meulemans, Tommi
scheme or table, p. 6890 - 6894 (2011/02/25)
The trifluoromethylphenyl P2 motif from previously reported heteroarylnitrile series has been successfully applied for the design and synthesis of highly potent novel ketoamide-based cathepsin S inhibitors. The key in this process is the change of the tor
THE USE OF SELECTIVE P2X7 RECEPTOR ANTAGONISTS
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Page/Page column 64, (2008/06/13)
The present invention relates to the use of selective P2X7 receptor antagonists of formula (I), or a pharmaceutically acceptable salt or prodrug thereof wherein D, R1 and R2 are as defined in claim 1, for the treatment of neuropathic pain, chronic inflammatory pain, inflammation, neurodegeneration and for promoting neuroregeneration.
Structure-activity relationship studies on a series of novel, substituted 1-benzyl-5-phenyltetrazole P2X7 antagonists
Nelson, Derek W.,Gregg, Robert J.,Kort, Michael E.,Perez-Medrano, Arturo,Voight, Eric A.,Wang, Ying,Grayson, George,Namovic, Marian T.,Donnelly-Roberts, Diana L.,Niforatos, Wende,Honore, Prisca,Jarvis, Michael F.,Faltynek, Connie R.,Carroll, William A.
, p. 3659 - 3666 (2007/10/03)
1-Benzyl-5-aryltetrazoles were discovered to be novel antagonists for the P2X? receptor. Structure-activity relationship (SAR) studies were conducted around both the benzyl and phenyl moieties. In addition, the importance of the regiochemical substitution
