870074-01-4

Upstream product

• 402831-54-3 ethyl 2-azido-3,4,6-tri-O-acetyl-2-deoxy-1-thio-α-D-mannopyranoside 
• 402831-56-5 ethyl 2-azido-2-deoxy-1-thio-α-D-mannopyranoside 
• 870074-00-3 2-(benzyloxycarbonyl)aminoethyl 3,4-di-O-acetyl-2-azido-6-O-(tert-butyldimethylsilyl)-2-deoxy-α-D-mannopyranoside 
• 68733-20-0 1,3,4,6-tetra-O-acetyl-2-azido-2-deoxy-α-D-mannopyranoside 
• 870073-99-7 ethyl 3,4-di-O-acetyl-2-azido-6-O-(tert-butyldimethylsilyl)-2-deoxy-1-thio-α-D-mannopyranoside 

Relevant academic research and scientific papers

IMMUNOGENS FOR MENINGITIDIS-A VACCINES

An oligosaccharide useful for a Meningitidis A vaccine contains a first mannose unit having a spacer in the alpha configuration at C-1, which spacer is capable of conjugating to a protein, and which is connected to a second mannose unit through a 1,6-linkage which connects C-6 of the first unit to C-1 of the second unit, wherein the 1,6-linkage comprises a phosphonate. Related methods of making such compounds, analogous compounds, or intermediates thereof are also disclosed.

Synthesis of structures corresponding to the capsular polysaccharide of Neisseria meningitidis group A

Four differently substituted trimers of the CPS repeating unit have been synthesised in order to investigate the dependence on oligosaccharide size, acetylation and mode of phosphorylation of glycoconjugate vaccines against Neisseria meningitidis group A.