870076-76-9Relevant academic research and scientific papers
Novel tumor-targeted RGD peptide-camptothecin conjugates: Synthesis and biological evaluation
Dal Pozzo, Alma,Ni, Ming-Hong,Esposito, Emiliano,Dallavalle, Sabrina,Musso, Loana,Bargiotti, Alberto,Pisano, Claudio,Vesci, Loredana,Bucci, Federica,Castorina, Massimo,Fodera, Rosanna,Giannini, Giuseppe,Aulicino, Concetta,Penco, Sergio
, p. 64 - 72 (2010)
Five RGD peptide-camptothecin (CPT) conjugates were designed and synthesized with the purpose to improve the therapeutic index of this antitumoral drug family. New RGD cyclopeptides were selected on the basis of their high affinity to αv integr
7-T-BUTOXYIMINOMETHYLCAMPTOTHECIN CONJUGATED IN POSITION 20 WITH INTEGRIN ANTAGONISTS
-
Page/Page column 11, (2008/06/13)
Compounds of Formula (I) are described; in which the R1 group is as defined in the specification and includes the condensation of 7-t-butoxyiminomethylcamptothecin in position 20 with a cyclopeptide containing the RGD sequence. Said compounds are endowed
CAMPTOTHECIN DERIVATIVES CONJUGATED IN POSITION 20 WITH INTEGRIN ANTAGONISTS
-
Page/Page column 10, (2010/02/14)
Compounds or formula (I) are described, in which R and R1 groups are as defined here below and include the condensation of the camptothecin molecule in position 20 with a cyclopeptide containing the RGD sequence. Said compounds are endowed both
