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Apilimod Mesylate is a small molecule inhibitor of the IL-12/IL-23 pathways, demonstrating promising results in preclinical and clinical studies for the treatment of various autoimmune diseases. It functions by inhibiting the production of pro-inflammatory cytokines, reducing the activation of immune cells, and suppressing the activity of dendritic cells, which are pivotal in the immune response. Additionally, Apilimod Mesylate has the potential to modulate the activity of regulatory T cells, aiding in the restoration of immune system balance and alleviating autoimmune disease symptoms.

870087-36-8

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870087-36-8 Usage

Uses

Used in Pharmaceutical Industry:
Apilimod Mesylate is used as a therapeutic agent for the treatment of autoimmune diseases such as rheumatoid arthritis and multiple sclerosis. It is utilized for its ability to inhibit the production of pro-inflammatory cytokines, reduce immune cell activation, and suppress dendritic cell activity, thereby potentially alleviating symptoms and managing the progression of these conditions.
Used in Immunology Research:
In the field of immunology, Apilimod Mesylate serves as a valuable tool for studying the IL-12/IL-23 pathways and their role in autoimmune diseases. Its mechanism of action provides insights into the modulation of immune responses and the potential for developing new treatments targeting these pathways.
Used in Clinical Trials:
Apilimod Mesylate is used in clinical trials to evaluate its safety, efficacy, and optimal dosage for treating various autoimmune conditions. The results from these trials contribute to the understanding of its therapeutic potential and inform future treatment strategies for patients suffering from autoimmune diseases.

Check Digit Verification of cas no

The CAS Registry Mumber 870087-36-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,0,0,8 and 7 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 870087-36:
(8*8)+(7*7)+(6*0)+(5*0)+(4*8)+(3*7)+(2*3)+(1*6)=178
178 % 10 = 8
So 870087-36-8 is a valid CAS Registry Number.

870087-36-8Upstream product

870087-36-8Downstream Products

870087-36-8Relevant academic research and scientific papers

PROCESS FOR PREPARING MESYLATE SALTS OF IL-12 INHIBITORY COMPOUNDS

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Page/Page column 158, (2008/06/13)

This invention relates to a method of preparing mesylate salts of compounds that inhibit IL-12, IL-23 and/or IL-27 production.

DISALT INHIBITORS OF IL-12 PRODUCTION

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Page/Page column 65-66, (2008/06/13)

This invention relates to disalt nitrogen-heteroaryl inhibitors of IL-12 production, and related methods and pharmaceutical compositions.

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