870119-18-9Relevant academic research and scientific papers
A bidirectional SE′ strategy for 1,5- syn and 1,5- anti stereocontrol toward the synthesis of complex polyols
Williams, David R.,Claeboe, Christopher D.,Liang, Bo,Zorn, Nicolas,Chow, Nicholas S. C.
, p. 3866 - 3869 (2012/09/22)
Studies report a bidirectional SE′ strategy applicable for the stereocontrolled synthesis of nonracemic 1,5-syn and 1,5-anti diols and their derivatives. Nonracemic 1,3,2-diazaborolidine auxiliaries are incorporated by chemoselective tin-boron exchange to provide reactive allylic boranes. The convergent pathway utilizes sequential reactions with two aldehydes producing stereochemical outcomes from cyclic, closed, and open transition state preferences, respectively. Synthesis of fragment 16 of peloruside A is accomplished in four steps from readily available aldehydes 9 and 13.
Stereochemical assignment of the C1-C6 fragment of psymberin by synthesis and natural product degradation
Green, Michael E.,Rech, Jason C.,Floreancig, Paul E.
, p. 4117 - 4120 (2007/10/03)
(Chemical Equation Presented) Psymberin is a sponge-derived natural product that shows striking selectivity as a cytotoxic agent. Conformational mobility has precluded stereochemical assignment for the acyl fragment of this molecule (psymberic acid) by NM
