870119-93-0Relevant articles and documents
Pyrazolo[3,4-c]pyridazines as novel and selective inhibitors of cyclin-dependent kinases
Bra?a, Miguel F.,Cacho, Mónica,García, M. Luisa,Mayoral, Elena P.,López, Berta,De Pascual-Teresa, Beatriz,Ramos, Ana,Acero, Nuria,Llinares, Francisco,Mu?oz-Mingarro, Dolores,Lozach, Olivier,Meijer, Laurent
, p. 6843 - 6854 (2007/10/03)
Pyrazolopyridazine 1a was identified in a high-throughput screening carried out by BASF Bioresearch Corp. (Worcester, MA) as a potent inhibitor of CDK1/cyclin B and shown to have selectivity for the CDK family. Analogues of the lead compound have been syn