870137-22-7

Upstream product

• 870137-21-6 (2S,3R)-3-(3-acetoxy-4-benzyloxyphenyl)-2-(tert-butoxycarbonylmethylamino)-3-hydroxypropionic acid methyl ester 
• 870137-18-1 (R)-4-((R)-1-hydroxy-1-methylprop-2-ynyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 821006-10-4 (4S,5R)-5-(3-acetoxy-4-benzyloxyphenyl)-2-(4-methoxyphenyl)-3-methyloxazolidine-4-carboxylic acid methyl ester 
• 821006-11-5 (4S,5R)-3-(3-acetoxy-4-benzyloxyphenyl)-3-hydroxy-2-methylaminopropionic acid methyl ester 
• 870137-17-0 (2S,3R)-3-(4-benzyloxy-3-hydroxyphenyl)-2-(tert-butoxycarbonylmethylamino)-3-hydroxypropionic acid benzyl ester 
• 870137-16-9 {[(2S,3S)-3-ethynyl-3-methyl-1-(2-nitrobenzenesulfonyl)-aziridine-2-carbonyl]amino}acetic acid tert-butyl ester 
• 960595-76-0 (2S,3R)-3-hydroxy-3-methyl-2-(2-nitro-benzenesulfonyl-amino)-pent-4-ynoic acid 
• 870137-19-2 (1R,2R)-N-(2-hydroxy-1-hydroxymethyl-2-methyl-but-3-ynyl)-2-nitrobenzenesulfonamide 
• 870137-20-5 (2S,3R)-[3-hydroxy-3-methyl-2-(2-nitrobenzenesulfonylamino)pent-4-ynoylamino]acetic acid tert-butyl ester 
• 1013210-17-7 (2S,3R)-3-(4-benzyloxy-3-hydroxyphenyl)-2-(tert-butoxycarbonylmethylamino)-3-hydroxypropionic acid 

Relevant academic research and scientific papers

Total synthesis and biological evaluation of ustiloxin natural products and two analogs

Synthetic investigations of ustiloxin natural products are described. The first total synthesis of ustiloxin F was completed in 15 steps via ethynyl aziridine ring-opening by a phenol derivative. The results of biological tests of synthetic ustiloxins D a

A convergent total synthesis of ustiloxin D via an unprecedented copper-catalyzed ethynyl aziridine ring-opening by phenol derivatives

(Chemical Equation Presented) The ustiloxins are a family of heterodetic cyclopeptides that have been isolated from the water extracts of false smut balls on the panicles of rice plants caused by the fungus Ustilaginoidea virens. A concise total synthesis of ustiloxin D has been achieved via an unprecedented ethynyl aziridine ring-opening of phenol derivatives. The longest linear sequence of the synthesis is 15 steps from commercially available compounds.