870171-42-9Relevant academic research and scientific papers
Novel water-soluble sedative-hypnotic agents: Isoindolin-1-one derivatives
Kanamitsu, Norimasa,Osaki, Takashi,Itsuji, Yutaka,Yoshimura, Masakazu,Tsujimoto, Hisashi,Soga, Manabu
, p. 1682 - 1688 (2008/12/21)
We developed new intravenous sedative-hypnotic compounds with the isoindolin-1-one skeleton focusing on the water-soluble property and in vivo safety. We synthesized approximately 170 derivatives and evaluated their hypnotic effects by intravenous administration of the compounds to mice. A series of the 2-phenyl-3-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]isoindolin-1-one analogs, 3(-), 5(-), 27(-), and 47(-) [JM-1232(-)], showed potent sedative-hypnotic activity with good water solubility and a wide safety margin. The hypnotic doses (HD50s) of these 4 compounds when administered to mice were 2.35, 1.90, 2.17, and 3.12 mg/kg, respectively, and the lethal doses (LD50s) were 88.67, 64.69, >120, and >120 mg/kg, respectively. The therapeutic indexes (LD50/HD50) were 37.73, 34.05, >55.30, and >38.46, respectively. Among these compound, 47(-) [JM-1232(-)] is being considered as the most potential candidate for clinical trials in humans.
NEUROGENIC PAIN CONTROL AGENT COMPOSITION
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Page/Page column 13, (2008/06/13)
The instant application provides a pharmaceutical composition for controlling neuropathic pain, which comprises a compound of formula: or a salt thereof.
