870220-99-8

Basic information

• Product Name: 2-methyl-2-(2-nitro-4-trifluoromethyl-phenyl)-propionitrile
• Synonyms: 2-methyl-2-(2-nitro-4-trifluoromethyl-phenyl)-propionitrile
• CAS NO: 870220-99-8
• Molecular Weight: 258.2
• Mol File: 870220-99-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-methyl-2-(2-nitro-4-trifluoromethyl-phenyl)-propionitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-2-(2-nitro-4-trifluoromethyl-phenyl)-propionitrile(870220-99-8)
• EPA Substance Registry System: 2-methyl-2-(2-nitro-4-trifluoromethyl-phenyl)-propionitrile(870220-99-8)

Safety Data

• Hazardous Substances Data: 870220-99-8(Hazardous Substances Data)

Upstream product

• 13544-06-4 [2-nitro-4-(trifluoromethyl)phenyl]acetonitrile 
• 74-88-4 methyl iodide 

Downstream Products

• 870221-00-4 2-methyl-2-(2-nitro-4-trifluoromethyl-phenyl)-propylamine 

Relevant articles and documents

PROTEIN KINASE MODULATORS AND METHOD OF USE

The present invention relates to chemical compounds having a general formula I wherein A, B, D, E, G, H1-5 and R1-4 are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of these kinases. For example, the compounds are capable of modulating kinase enzymes thereby influencing the process of angiogenesis and treating angiogenesis-related diseases and other poliferative disorders, including cancer and inflammation. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of protein kinases.