87032-71-1Relevant articles and documents
Amine, 1, 2-and 1, 3-diol, and its use for curing Alzheimer's disease
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Page/Page column 217, (2008/06/13)
Disclosed are compounds of formula: and pharmaceutically acceptable salts and esters thereof, useful in treating and/or preventing Alzheimer's disease and other similar diseases, wherein RN, RC, R1, n and R20 are defined herein. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
2-Amino-1-(1,2-dioxolan-4-yl)ethanol compounds, their preparation and use
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, (2008/06/13)
2-Amino-1-(1,3-dioxolan-4-yl)ethanol compounds of formula (I) STR1 wherein R1 and R2 are identical or different and can be hydrogen or a lower alkyl group of 1-4 carbon atoms; or when R2 is an alkyl group of 1-4 carbon atoms, R1 can also be an alkoxy group of 1-4 carbon atoms; or R1 and R2 combined form an alkylene residue of 5 or 6 carbon atoms, are especially suited as intermediates in the production of opacifying compounds useful in X-ray contrast media.
