87032-82-4

Usage

Uses

Used in Pharmaceutical Industry:
3-Hydroxypyridine-4-carbonitrile is used as a building block for the synthesis of pharmaceuticals due to its ability to be incorporated into various drug molecules, contributing to their therapeutic properties.
Used in Agrochemical Industry:
3-hydroxypyridine-4-carbonitrile also serves as a key intermediate in the production of agrochemicals, where it can be used to create compounds that protect crops from pests and diseases.
Used as an Anti-Inflammatory Agent:
3-Hydroxypyridine-4-carbonitrile is used as an anti-inflammatory agent, leveraging its biological activity to reduce inflammation and provide relief in conditions characterized by swelling and discomfort.
Used as an Analgesic:
Additionally, it is used as an analgesic, helping to alleviate pain by interacting with the body's pain response mechanisms, offering an alternative to traditional pain management options.

Upstream product

• 15031-12-6 5-ethoxyoxazole 
• 107-13-1 acrylonitrile 
• 878194-91-3 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-4-carbonitrile 
• 68325-15-5 3-chloro-isonicotinonitrile 
• 14906-59-3 4-cyanopyridine N-oxide 
• 10128-73-1 3-hydroxyisonicotinamide 
• 945989-08-2 3-(2-(trimethylsilyl)ethoxy)isonicotinonitrile 

Downstream Products

• 927804-72-6 ethyl 3-aminofuro[2,3-c]pyridine-2-carboxylate 

Relevant academic research and scientific papers

2-AMINOPYRIDINE DERIVATIVES AS GLUCOKINASE ACTIVATORS

Provided are compounds having the Formula (I) or salts thereof, wherein: L is O, S, SO, SO2, CHOH, C(O), or CH2; D2 is CR12 or N; R2 is aryl, heteroaryl, saturated or partially unsaturated cycloalkyl, or saturated or partially unsaturated heterocyclyl (optionally substituted with oxo), wherein said aryl, heteroaryl, cycloalkyl and heterocyclyl are monocyclic or bicyclic and are further optionally substituted with one or more groups independently selected from C1-C6 alkyl, F, Cl, Br, I, CF3, CN, OR6, C(=O)R6, C(=O)OR6, O(CH2)nC(=O)OR6, C(=O)NR6R7, NO2 and (1-6C alkyl)OR6; R3 is H, Br, OR6, SR6, C(O)OR6, C(O)NR6R7, C(O)R6, heteroaryl, or C1-C6 alkyl substituted with one or more groups independently selected from Vn-aryl, Vn-OR6, Vn- C(=O)OR6 and Vn-NR6R7; R11 is H or Cl; and R13 is N-(1 -6C alkanoyl)piperidin-4-yl; that are useful in the treatment and/or prevention of diseases mediated by deficient levels of glucokinase activity, such as diabetes mellitus. Also provided are methods of treating or preventing diseases and disorders characterized by underactivity of glucokinase or which can be treated by activating glucokinase.

GLUCOKINASE ACTIVATORS

Provided are compounds of formula I that are useful in the treatment and/or prevention of diseases mediated by deficient levels of glucokinase activity, such as diabetes mellitus. Also provided are methods of treating or preventing diseases and disorders characterized by underactivity of glucokinase or which can be treated by activating glucokinase. (Formula I) wherein R2, L, Z, Y, G and R1 are as defined in the claims.

Straightforward access to ethyl 3-aminofuropyridine-2-carboxylates from 1-chloro-2-cyano- or 1-hydroxy-2-cyano-substituted pyridines

The conditions of the synthesis of the four regioisomers of ethyl 3-aminofuropyridine-2-carboxylate are described and discussed in detail. The starting materials are either 1-chloro-2-cyanopyridines or 1-cyano-2- hydroxypyridines. Georg Thieme Verlag Stuttgart.

FUSED FURAN COMPOUND

The present invention provides a condensed furan compound of the formula (I): wherein Ring X is benzene, pyridine, or the like; Y is an optionally substituted amino, an optionally substituted cycloalkyl, an optionally substituted aryl, an optionally substituted saturated heterocyclic group, an optionally substituted unsaturated heterocyclic group; A is a single bond, lower alkylene, lower alkenylidene, lower alkenylene or an oxygen atom; R3 is hydrogen or the like; and , R4 is hydrogen, or the like, or pharmaceutically acceptable salts thereof, which is useful as a medicament, particularly, as an activated blood coagulation factor X inhibitor.

Oxazoles in Diels-Alder Reactions. Transformation of The Adducts to Either Pyridines or Pyrroles

The cycloadducts between acrylic acid or acrylonitrile and 5-ethoxyoxazoles are converted as formed to 3-hydroxypyridines.The Diels-Alder adducts from ethyl acrylate, or methyl or phenyl vinyl ketone can be isolated.In ethanolic HCl the adducts are transformed into 3-hydroxypyridines; in aqueous HCl the products are acylpyrrole analogues.A 4-substituent in the oxazole affects the reaction. 4-Methyl-5-ethoxyoxazole reacts much faster than its 5-ethylthio analogue.