87035-97-0

Upstream product

• 78833-85-9 2-<3-benzyl-6-oxo-2-thia-4,7-diaza-(1R,5R)-bicyclo-<3.2.0>-hept-3-en-7-yl>-t-butyl and p-nitrobenzyl malonate 
• 619-73-8 4-nitrobenzyl chloride 

Downstream Products

• 76227-81-1 (6R)-phenylacetamido-2-methoxy-(5R)-penem-3-t-butyl-carboxylate 
• 76227-80-0 2-oxo-bisnorpenicillin G-3-t-butyl carboxylate 
• 87035-95-8 (5R,6R)-3-Methylsulfanyl-7-oxo-6-phenylacetylamino-4-thia-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid tert-butyl ester 
• 87035-93-6 (2S,5R,6R)-7-Oxo-6-phenylacetylamino-3-thioxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid tert-butyl ester 
• 87035-92-5 (5R,6R)-7-Oxo-6-phenylacetylamino-3-thioxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2,2-dicarboxylic acid tert-butyl ester 4-nitro-benzyl ester 
• 87035-90-3 (5R,6R)-3,7-Dioxo-6-phenylacetylamino-4-thia-1-aza-bicyclo[3.2.0]heptane-2,2-dicarboxylic acid tert-butyl ester 4-nitro-benzyl ester 

Relevant academic research and scientific papers

A GENERAL ROUTE TOWARD 2-OXO-, 2-THIOXO- AND 2-IMINOPENAMS AND THEIR CONVERSION INTO 2-ALKOXY-, 2-ALKYLTHIO- AND 2-AMINOPENEMS

A convenient methodology is described which allows the preparation of 2-oxo-, 2-thioxo- and 2-iminopenams from a single precursor readily prepared from penicillin G.These penams have been converted into the corresponding 2-heterosubstituted penems.