870486-22-9Relevant academic research and scientific papers
Structure-based design and synthesis of benzimidazole derivatives as dipeptidyl peptidase IV inhibitors
Wallace, Michael B.,Feng, Jun,Zhang, Zhiyuan,Skene, Robert J.,Shi, Lihong,Caster, Christopher L.,Kassel, Daniel B.,Xu, Rongda,Gwaltney II, Stephen L.
, p. 2362 - 2367 (2008)
A novel series of non-covalent, benzimidazole-based inhibitors of DPP-4 has been developed from a small fragment hit using structure-based drug design. A highly versatile synthetic route was created for the development of SAR, which led to the discovery o
