870541-16-5 Usage
Molecular weight
263.66 g/mol This is the mass of one mole of 2-(2-CHLORO-4-NITROPHENOXY)-2-METHYLPROPANOIC ACID, expressed in grams per mole (g/mol).
Class of compound
Carboxylic acid This refers to the type of chemical compound, which is characterized by the presence of a carboxyl functional group (-COOH).
Derivative of phenoxyacetic acid
Yes This indicates that 2-(2-CHLORO-4-NITROPHENOXY)-2-METHYLPROPANOIC ACID is a modified version of phenoxyacetic acid, a naturally occurring plant hormone.
Contains a nitro group
Yes This refers to the presence of a -NO2 functional group in the molecule, which is known for its explosive and reactive properties.
Contains a chlorine atom
Yes This indicates the presence of a chlorine atom in the molecule, which can affect the compound's reactivity and properties.
Used as an intermediate in the synthesis of pharmaceuticals and agrochemicals
Yes This means that 2-(2-CHLORO-4-NITROPHENOXY)-2-METHYLPROPANOIC ACID is used as a starting material or building block in the production of other chemicals, specifically in the manufacture of drugs and pesticides.
Check Digit Verification of cas no
The CAS Registry Mumber 870541-16-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,0,5,4 and 1 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 870541-16:
(8*8)+(7*7)+(6*0)+(5*5)+(4*4)+(3*1)+(2*1)+(1*6)=165
165 % 10 = 5
So 870541-16-5 is a valid CAS Registry Number.
870541-16-5Relevant articles and documents
Exploration of a 14-3-3 PPI Pocket by Covalent Fragments as Stabilizers
Sijbesma, Eline,Hallenbeck, Kenneth K.,Andrei, Sebastian A.,Rust, Reanne R.,Adriaans, Joris M. C.,Brunsveld, Luc,Arkin, Michelle R.,Ottmann, Christian
, p. 976 - 982 (2021)
The systematic discovery of functional fragments binding to the composite interface of protein complexes is a first critical step for the development of orthosteric stabilizers of protein-protein interactions (PPIs). We have previously shown that disulfide trapping successfully yielded covalent stabilizers for the PPI of 14-3-3 with the estrogen receptor ERα. Here we provide an assessment of the composite PPI target pocket and the molecular characteristics of various fragments binding to a specific subpocket. Evaluating structure-activity relationships highlights the basic principles for PPI stabilization by these covalent fragments that engage a relatively large and exposed binding pocket at the protein/peptide interface with a "molecular glue"mode of action.
