870634-63-2Relevant academic research and scientific papers
METHOD FOR PRODUCING DIPHENYL AZETIDINONE DERIVATIVES
-
Page/Page column 59-60, (2008/06/13)
The invention relates to a method for producing diphenyl azetidinone derivatives of general formula (I) or forms protected in the substituents X, R1 and/or R2, wherein the symbols, substituents, and indices have the following designations: X = H, OH; Rl = OH, OCH3; R2 = F, CH2CH3, CH2NHR4; R3 = H, F; R4 = H, CO-(CH2-)nCO-R5, CO-(CH2-)nNHR6; n = whole numbers from 4 to 16; R5 = OH, NH-CH2-[CH(OH)-]mCH2OH; R6 = H, CO-[CH(OH)-]mCH2OH; and m = whole numbers from 1 to 5. According to said method, novel compounds of general formula (II), wherein Y = H, H; H, OH; H, OAc; H, OSi(alkyl)o(aryl)p where o, p = 0, 1, 2 or 3 and o + p = 3; H, OTHP; H, OC(Aryl)3; H, OCH2OAlkyl; H, OCH(OAlkyl)CH3; H, OAlkyl; H, OCH2aryl; Oalkyl, Oalkyl; and cyclic ketone acetyl such as O-(CH2-)q-O where q = 2 or 3, are reacted with imines of general formula (III) wherein R7 = R1and O protective groups and R8 = e.g. R2.
