870646-72-3

Upstream product

• 870646-71-2 (1R,2S,4R,5S)-5-[(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)methyl]-4-iodobicyclo[3.1.0]hex-2-yl benzoate 
• 870646-69-8 (1R,2S,4S,5S)-4-hydroxy-5-(hydroxymethyl)bicyclo[3.1.0]hex-2-yl benzoate 
• 870646-68-7 (1R,2S,4S,5S)-4-hydroxy-5-[(phenylmethoxy)methyl]bicyclo[3.1.0]hex-2-yl benzoate 
• 870646-66-5 (1R,2S,4S,5S)-4-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)-5-[(phenylmethoxy)methyl]bicyclo[3.1.0]hexan-2-ol 
• 870646-70-1 (1R,2S,4S,5S)-5-[(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)methyl]-4-hydroxybicyclo[3.1.0]hex-2-yl benzoate 
• 870646-67-6 (1R,2S,4S,5S)-4-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)-5-[(phenylmethoxy)methyl]bicyclo[3.1.0]hex-2-yl benzoate 
• 325464-37-7 (1S,4S)-4-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)-3-[(phenylmethoxy)methyl]cyclopent-2-en-1-ol 

Downstream Products

• 870646-74-5 (1'R,2'R,5'S)-1-{5-[(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)methyl]bicyclo[3.1.0]hex-3-en-2-yl}-5-methyl-3-(phenylcarbonyl)-1,3-dihydropyrimidine-2,4-dione 
• 917483-18-2 1-[5-(tert-butyl-diphenyl-silanyloxymethyl)-bicyclo[3.1.0]hex-3-en-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 
• 870646-73-4 (1R,2S,5S)-5-[(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)methyl]bicyclo[3.1.0]hex-3-en-2-ol 

Relevant academic research and scientific papers

Understanding how the herpes thymidine kinase orchestrates optimal sugar and nucleobase conformations to accommodate its substrate at the active site: A chemical approach

The herpes virus thymidine kinase (HSV-tk) is a critical enzyme for the activation of anti-HSV nucleosides. However, a successful therapeutic outcome depends not only on the activity of this enzyme but also on the ability of the compound(s) to interact ef