870700-46-2

Upstream product

• 502687-22-1 [(2R,3S,3aR,5S,6R,6aR)-3,6-Bis-(tert-butyl-diphenyl-silanyloxy)-5-triethylsilanyloxy-hexahydro-furo[3,2-b]furan-2-yl]-methanol 
• 502687-21-0 (3R,3aR,5S,6R,6aR)-3,6-Bis-(tert-butyl-diphenyl-silanyloxy)-2-methylene-5-triethylsilanyloxy-hexahydro-furo[3,2-b]furan 
• 502687-18-5 (3R,3aR,5S,6R,6aR)-3,6-Bis-(tert-butyl-diphenyl-silanyloxy)-5-triethylsilanyloxy-tetrahydro-furo[3,2-b]furan-2-one 
• 502687-24-3 2,2-Dimethyl-propionic acid (2R,3R,4R,5R)-3-(tert-butyl-diphenyl-silanyloxy)-5-[(E)-(S)-1-(tert-butyl-diphenyl-silanyloxy)-3-methoxy-allyl]-4-hydroxy-tetrahydro-furan-2-ylmethyl ester 
• 502687-20-9 (3R,3aR,6R,6aR)-3,6-Bis-(tert-butyl-diphenyl-silanyloxy)-5-hydroxy-tetrahydro-furo[3,2-b]furan-2-one 
• 108-24-7 acetic anhydride 
• 870700-43-9 2,2-Dimethyl-propionic acid (2R,3S,3aR,5S,6R,6aR)-3,6-bis-(tert-butyl-diphenyl-silanyloxy)-5-triethylsilanyloxy-hexahydro-furo[3,2-b]furan-2-ylmethyl ester 

Downstream Products

• 870700-31-5 [(2R,3S,3aR,4aS,7R,8aS,9S,9aR)-2-((E)-4-{(2S,5S)-5-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-4-methylene-tetrahydro-furan-2-yl}-2-methoxy-but-1-enyl)-3,9-bis-triethylsilanyloxy-decahydro-furo[3,2-b]pyrano[2,3-e]pyran-7-yl]-acetic acid methyl ester 

Relevant academic research and scientific papers

Halichondrin B: Synthesis of the C1-C22 subunit

Two efficient routes to the C1-C22 subunit of halichondrin B are described. The cage ketal 7, which contains 11 asymmetric centers embedded within the ABCDEF-ring framework, was assembled from (+)-conduritol E (27) in 18 steps and 4% overall yield. In a s