870709-73-2Relevant academic research and scientific papers
Asymmetric alkylation of 5-alkyl-2-aminothiazolones using a C 2-symmetric chiral tetraamine base
Frizzle, Matthew J.,Nani, Roger R.,Martinelli, Michael J.,Moniz, George A.
, p. 5613 - 5616 (2011)
The diastereoselective alkylation of a series of 5-alkyl-2-aminothiazolones utilizing a C2-symmetric chiral tetraamine base is reported.
PROCESS FOR MAKING SUBSTITUTED 2-AMINO-THIAZOLONES
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Page/Page column 34-36, (2010/04/03)
The present invention relates to methods of making compounds that inhibit 11-β-hydroxysteroid dehydrogenase type 1 enzyme (11-β HSD1). One method comprises (a) contacting a compound of formula (II) with a chiral base, deprotonating agent, and an alkylating agent R3-LG, (b) contacting the product of (a) with an acid to form a salt, and (c) reacting the salt with a base to form the compound of formula (I); wherein Z, R1, R2, and R3 are defined herein.
INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1
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Page/Page column 175, (2008/06/13)
The present invention relates to thiazolinones and also to pharmaceutical compositions comprising the compounds, as well as methods of use of the compounds for treatment of disorders associated with human 11-β-hydroxysteroid dehydrogenase type 1 enzyme an
