870753-90-5Relevant articles and documents
Synthesis and characterization of the novel fluorescent prolyl oligopeptidase inhibitor 4-fluoresceinthiocarbamoyl-6-aminocaproyl-L-prolyl-2(S) -(hydroxyacetyl)pyrrolidine
Ven?l?inen, Jarkko I.,Wallén, Erik A. A.,Poso, Antti,García-Horsman, J. Arturo,M?nnist?, Pekka T.
, p. 7093 - 7095 (2007/10/03)
The synthesis and characterization of the first fluorescent prolyl oligopeptidase inhibitor 4-fluoresceinthiocarbamoyl-6-aminocaproyl-L-prolyl-2(S) -(hydroxyacetyl)prrolidine is described. This compound has an IC50 value of 0.83 nM and a dissociation half-life of 160 min, and its fluorescence signal is detectable using standard filters for fluorescein. These properties make this compound a suitable probe for visualizing prolyl oligopeptidase in various applications.