870766-00-0 Usage
Structure
1H-Indazole-1-carboxylic acid, 3-bromo-5-methoxy-, 1,1-dimethylethyl ester is a derivative of indazole, which is a five-membered aromatic ring containing four carbon atoms and one nitrogen atom. The carboxyl group (-COOH) is attached to the nitrogen atom at position 1 of the indazole ring. A bromine atom (Br) is attached to the carbon atom at position 3 of the indazole ring, and a methoxy group (-OCH3) is attached to the carbon atom at position 5. The ester group (-OC(CH3)3) is attached to the carboxyl group.
Usage
1H-Indazole-1-carboxylic acid, 3-bromo-5-methoxy-, 1,1-dimethylethyl ester is commonly used in organic synthesis and medicinal chemistry as a building block in the synthesis of various pharmaceutical products and research chemicals.
Biological activity
1H-Indazole-1-carboxylic acid, 3-bromo-5-methoxy-, 1,1-dimethylethyl ester has shown to possess biological activity and has been studied for its potential use in the treatment of various medical conditions.
Pharmacological and therapeutic applications
Due to its structural and chemical properties, 1H-Indazole-1-carboxylic acid, 3-bromo-5-methoxy-, 1,1-dimethylethyl ester has potential pharmacological and therapeutic applications.
Check Digit Verification of cas no
The CAS Registry Mumber 870766-00-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,0,7,6 and 6 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 870766-00:
(8*8)+(7*7)+(6*0)+(5*7)+(4*6)+(3*6)+(2*0)+(1*0)=190
190 % 10 = 0
So 870766-00-0 is a valid CAS Registry Number.
870766-00-0Relevant articles and documents
Aminopiperidine indazoles as orally efficacious melanin concentrating hormone receptor-1 antagonists
Vasudevan, Anil,Souers, Andrew J.,Freeman, Jennifer C.,Verzal, Mary K.,Gao, Ju,Mulhern, Mathew M.,Wodka, Derek,Lynch, John K.,Engstrom, Kenneth M.,Wagaw, Seble H.,Brodjian, Sevan,Dayton, Brian,Falls, Doug H.,Bush, Eugene,Brune, Michael,Shapiro, Robin D.,Marsh, Kennan C.,Hernandez, Lisa E.,Collins, Christine A.,Kym, Philip R.
, p. 5293 - 5297 (2005)
The synthesis and biological evaluation of novel 3-amino indazole melanin concentrating hormone receptor-1 antagonists are reported, several of which demonstrated functional activity of less than 100 nM. Compounds 19 and 28, two of the more potent compounds identified in this study, were characterized by high exposure in the brain and demonstrated robust efficacy when dosed in diet-induced obese mice.
