870766-44-2

Upstream product

• 51-17-2 benzoimidazole 
• 2417-72-3 Methyl 4-(bromomethyl)benzoate 
• 615-36-1 2-bromoaniline 
• 18469-52-8 methyl 4-(aminomethyl)benzoate 
• 53746-69-3 N,N-Dimethyl-N'-2-bromphenylformamidin 

Downstream Products

• 870766-46-4 4-benzoimidazol-1-ylmethyl-benzoic acid hydrazide 
• 139742-50-0 4-((1H-benzo[d]imidazol-1-yl)methyl)benzoic acid 
• 118001-88-0 4-((1H-benzo[d]imidazol-1-yl)methyl)benzaldehyde 
• 1087328-34-4 4-(1H-benzimidazol-1-ylmethyl)-N-methyl-N-[(3R)-pyrrolidin-3-yl]benzamide 
• 1087328-33-3 3-[(4-benzoimidazol-1-ylmethyl-benzoyl)-methyl-amino]-(R)-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 1087328-32-2 (R)-tert-butyl 3-(4-((1H-benzo[d]imidazol-1-yl)methyl)benzamido)-pyrrolidine-1-carboxylate 
• 1087386-42-2 4-(1H-benzimidazol-1-ylmethyl)-N-[(3R)-1-cyclopentylpyrrolidin-3-yl]-N-methylbenzamide 
• 1087334-22-2 4-(1H-benzimidazol-1-ylmethyl)-N-[(3R)-1-cyclobutylpyrrolidin-3-yl]-N-methylbenzamide 
• 1087386-41-1 4-(1H-benzimidazol-1-ylmethyl)-N-[(3R)-1-isopropylpyrrolidin-3-yl]-N-methylbenzamide 

Relevant academic research and scientific papers

Lanthanide luminescent coordination polymer constructed from unsymmetrical dinuclear building blocks based on 4-((1H-benzo[d]imidazol-1-yl)methyl)benzoic acid

Lanthanide coordination polymers of the general formula [Ln 2(L)5(NO3)(H2O)4] n (Ln = Eu (1), Tb (2), Gd (3)) supported by a novel aromatic carboxylate ligand 4-((1H-benzo[d]imidazol-1-yl)m

Convenient synthesis of N-1-alkyl benzimidazoles via Pd catalyzed C–N bond formation and cyclization

N-1-Alkyl-2-unsubstituted benzimidazoles were directly synthesized by intermolecular coupling of formimidamides with benzylamines; the syntheses were catalyzed by Pd(OAc)2 in one pot, giving rise to moderate to good yields. Aromatic formamidine

A Photochemical/Thermal Switch Based on 4,4′-Bis(benzimidazolio)stilbene: Synthesis and Supramolecular Properties.

Stilbene derivatives are well-recognised substructures of molecular switches based on photochemically and/or thermally induced (E)/(Z) isomerisation. We combined a stilbene motif with two benzimidazolium arms to prepare new sorts of supramolecular buildin

Synthesis of coordination polymers with d10 metal ions and a new linear ligand: X-ray structural and luminescence studies

Four new coordination polymers (CPs), {[Zn2(L) 4]·7H2O}n (1), {[Zn2(L) 4]·4H2O}n (2), {[Zn(L) 2]·3/2H2O}n (3) and {[Cd(L) 2

HDAC INHIBITORS AND THERAPEUTIC METHODS USING THE SAME

Histone deacetylases inhibitors (HDACIs) and compositions containing the same are disclosed. Methods of treating diseases and conditions wherein inhibition of HDAC provides a benefit, like a cancer, a neurodegenerative disorder, a peripheral neuropathy, a neurological disease, traumatic brain injury, stroke, hypertension, malaria, an autoimmune disease, autism, autism spectrum disorders, and inflammation, also are disclosed.

Pyrrolidin-3-yl-N-methylbenzamides as potent histamine 3 receptor antagonists

On the basis of the previously reported benzimidazole 1,3′- bipyrrolidine benzamides (1), a series of related pyrrolidin-3-yl-N- methylbenzamides were synthesized and evaluated as H3 receptor antagonists. In particular, compound 32 exhibits pot

Tricyclononene carboxamide derivatives as novel anti-HIV-1 agents

By modifying the chemical structure of anti-orthopoxvirus compound ST-246, we designed and synthesized a series of tricyclononene carboxamide derivatives and tested their anti-HIV-1 activity and cytotoxicity. We found that benzoimidazol-containing compound 7g was highly effective in inhibiting HIV-1 R5 infection with an IC50 value of 0.41 μM and a selectivity index of 292, but it exhibited no significant inhibitory activity on HIV-1 reverse transcriptase, integrase and protease. CoMFA was used to analyze structure-activity relationships with good predictive power (r2 = 0.921; q2 = 0.582). Moreover, the CoMFA model showed that the length of the molecule, the amide, and the amine moieties all played crucial roles in anti-HIV activity. These results suggest that 7g may serve as a lead for the development of novel anti-HIV-1 therapies. A series of tricyclononene carboxamide derivatives based on anti-orthopoxvirus compound ST-246 were synthesized and characterized as novel anti-HIV-1 agents.

AMINOALKYLAZOLE DERIVATIVES AS HISTAMINE-3 ANTAGONISTS

The present invention provides a compound of formula I: and the use thereof for the treatment of a central nervous system disorder related to or affected by the histamine-3 receptor.

AZACYCLYLBENZAMIDE DERIVATIVES AS HISTAMINE-3 ANTAGONISTS

The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the histamine-3 receptor

Histone deacetylase inhibitors

Compounds, pharmaceutical compositions, kits and methods are provided for use with histone deacetylases (HDACs) that comprise a compound of the formulae: wherein the variables are as defined herein.