870823-04-4

Basic information

• Product Name: tert-butyl N-[4-(1-hydroxyethyl)benzoyl]-β-alaninate
• Synonyms: tert-butyl N-[4-(1-hydroxyethyl)benzoyl]-β-alaninate
• CAS NO: 870823-04-4
• Molecular Weight: 293.363
• Mol File: 870823-04-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: tert-butyl N-[4-(1-hydroxyethyl)benzoyl]-β-alaninate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl N-[4-(1-hydroxyethyl)benzoyl]-β-alaninate(870823-04-4)
• EPA Substance Registry System: tert-butyl N-[4-(1-hydroxyethyl)benzoyl]-β-alaninate(870823-04-4)

Safety Data

• Hazardous Substances Data: 870823-04-4(Hazardous Substances Data)

Upstream product

• 586-89-0 4-acetyl-benzoic acid 
• 58620-93-2 tert-butyl 3-aminopropanoate hydrochloride 
• 870823-03-3 tert-butyl 3-(4-acetylbenzamido)propanoate 

Downstream Products

• 870823-06-6 tert-butyl N-{4-[1-(3-(6-methoxy-2-naphthyl)-5-{[(trifluoromethyl)sulfonyl]oxy}-1H-pyrazol-1-yl)ethyl]benzoyl}-β-alaninate 
• 870823-05-5 N-{4-[1-(5-(6-methoxy-2-naphthyl)-3-{[(trifluoromethyl)sulfonyl]oxy}-1H-pyrazol-1-yl)ethyl]benzoyl}-β-alaninate 

Relevant articles and documents

A novel series of 4-methyl substituted pyrazole derivatives as potent glucagon receptor antagonists: Design, synthesis and evaluation of biological activities

A novel series of 4-methyl substituted pyrazole derivatives were designed, synthesized and biologically evaluated as potent glucagon receptor (GCGR) antagonists. In this study, compounds 9q, 9r, 19d and 19e showed high GCGR binding (IC50 = 0.09 μM, 0.06 μM, 0.07 μM and 0.08 μM, respectively) and cyclic-adenosine monophosphate (cAMP) activities (IC50 = 0.22 μM, 0.26 μM, 0.44 μM and 0.46 μM, respectively) in cell-based assays. Most importantly, the docking experiment demonstrated that compound 9r formed extensive hydrophobic interactions with the receptor binding pocket, making it justifiable to further investigate the potential of becoming a GCGR antagonist.