871013-48-8Relevant academic research and scientific papers
Synthesis and evaluation of 4-substituted benzylamine derivatives as β-tryptase inhibitors
Miyazaki, Yutaka,Kato, Yutaka,Manabe, Tadashi,Shimada, Hiroyasu,Mizuno, Masashi,Egusa, Takayuki,Ohkouchi, Munetaka,Shiromizu, Ikuya,Matsusue, Tomokazu,Yamamoto, Ichiro
, p. 2986 - 2990 (2006)
Since β-tryptase is considered a critical mediator of asthma, potent tryptase inhibitors may be useful as new agents for the treatment of asthma. We investigated 4-substituted benzylamine derivatives and obtained M58539 (15h) as a potent inhibitor of β-tryptase (IC50 = 5.0 nM) with high selectivity against other serine proteases, low molecular weight, c log P value less than 5, lack of amidino and guanidino groups, and independence of Zn2+ ion.
