871022-62-7

Usage

Uses

Used in Pharmaceutical Industry:
Tert-butyl (4-fluoropiperidin-4-yl)methylcarbamate is used as a reagent for the preparation of cyanophenylglycine derivatives, which are of interest in the development of treatments for acute myeloid leukemia (AML). The derivatives may function as reversible inhibitors of lysine demethylase 1, a key enzyme involved in the differentiation of leukemia stem cells, thus offering a potential therapeutic approach to combat AML.

InChI:InChI=1/C11H21FN2O2/c1-10(2,3)16-9(15)14(4)11(12)5-7-13-8-6-11/h13H,5-8H2,1-4H3

Upstream product

• 455267-63-7 benzyl 4-(azidomethyl)-4-fluoropiperidine-1-carboxylate 
• 240400-84-4 benzyl 4-fluoro-4-(hydroxymethyl)piperidine-1-carboxylate 
• 77211-75-7 benzyl 1-oxa-6-aza-spiro[2.5]octane-6-carboxylate 
• 871022-60-5 N-benzoyl-4-tert-butoxycarbonylaminomethyl-4-fluoropiperidine 

Relevant academic research and scientific papers

HETEROBICYCLIC COMPOUNDS FOR INHIBITING THE ACTIVITY OF SHP2

A compound of formula (I):wherein Ring A, Q, R1,R2, R3, R4, R5, R6, R7, R8, R9, R10, R11,X, a,b, c and d are as defined in the specification.

Oxyindole derivatives

This invention relates to compounds of the formula (I): or a pharmaceutically acceptable salt thereof, wherein: A, R1, R2, R3, R4 and R5 are each as described herein or a pharmaceutically acceptable s

Benzimidazolone carboxylic acid derivatives

This invention relates to compounds of the formula (I): wherein R1, R2, R3, A and m are each as described herein or a pharmaceutically acceptable salt or solvate thereof, and compositions containing such compounds and the use of such compounds in the treatment of a condition mediated by 5-HT4 receptor activity such as, but not limited to, gastroesophageal reflux disease, gastrointestinal disease, gastric motility disorder, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome (IBS), constipation, dyspepsia, esophagitis, gastroesophageral disease, nausea, central nervous system disease, Alzheimer's disease, cognitive disorder, emesis, migraine, neurological disease, pain, cardiovascular disorders such as cardiac failure and heart arrhythmia, diabetes and apnea syndrome.