871022-90-1

Upstream product

• 851589-01-0 phosphoric acid di-tert-butyl ester 3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-octadec-9-enoylamino-propyl ester 
• 870862-63-8 Phosphoric acid di-tert-butyl ester (R)-3-(4-hydroxy-phenyl)-2-((Z)-octadec-9-enoylamino)-propyl ester 
• 851589-00-9 (Z)-Octadec-9-enoic acid {(R)-2-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-1-hydroxymethyl-ethyl}-amide 
• 851588-99-3 (R)-3-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-2-((Z)-octadec-9-enoylamino)-propionic acid methyl ester 
• 851588-98-2 (R)-3-(4-Hydroxy-phenyl)-2-((Z)-octadec-9-enoylamino)-propionic acid methyl ester 
• 851589-02-1 C₃₆H₆₁F₃NO₈PS 

Relevant academic research and scientific papers

NOVEL LYSOPHOSPHATIDIC ACID RECEPTOR SELECTIVE ANTAGONISTS

The present invention is directed to compositions comprising lysophosphatidic acid analogs and methods of using such analogs as agonist or antagonists of LPA receptor activity. In addition the invention is directed to LPA receptor agonists that vary in the degree of selectivity at individual LPA receptors (i.e. LPA1, LPA2 and LPA3). More particularly the present invention is directed to LPA analogs wherein the glycerol is replaced with ethanolamine and a variety of substitutions have been linked at the second carbon atom.