871108-86-0Relevant academic research and scientific papers
Asymmetric Total Syntheses of (-)-Fennebricin A, (-)-Renieramycin J, (-)-Renieramycin G, (-)-Renieramycin M, and (-)- Jorunnamycin A via C-H Activation
Zheng, Yu,Zheng, Yu,Li, Xue-Dan,Li, Xue-Dan,Sheng, Peng-Zhen,Yang, Hong-Dou,Yang, Hong-Dou,Wei, Kun,Yang, Yu-Rong
, p. 4489 - 4493 (2020)
Collective total synthesis of five tetrahydroisoquinoline alkaloids including the first total synthesis of (-)-fennebricin A and (-)-renieramycin J has been accomplished. The synthesis features employing a single common amino acid to symmetrically construct the pentacycle of title alkaloids. The palladium-catalyzed arylation of alanine-derived amide developed by Yu was tactically utilized to afford unnatural amino acid building block rapidly and practically. The structure of synthetic (-)-renieramycin M has been confirmed by single crystal X-ray analysis for the first time.
