871112-46-8

Basic information

• Product Name: ethyl 4-(4-chlorobenzyl)-4-hydroxypiperidine-1-carboxylate
• CAS NO: 871112-46-8
• Molecular Weight: 297.782
• Mol File: 871112-46-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: ethyl 4-(4-chlorobenzyl)-4-hydroxypiperidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 4-(4-chlorobenzyl)-4-hydroxypiperidine-1-carboxylate(871112-46-8)
• EPA Substance Registry System: ethyl 4-(4-chlorobenzyl)-4-hydroxypiperidine-1-carboxylate(871112-46-8)

Safety Data

• Hazardous Substances Data: 871112-46-8(Hazardous Substances Data)

Upstream product

• 104-83-6 1-Chloro-4-(chloromethyl)benzene 
• 29976-53-2 N-ethoxycarbonyl-4-piperidone 

Downstream Products

• 1998-02-3 4-[4-(4-chloro-benzyl)-4-hydroxy-piperidin-1-yl]-1-(4-fluoro-phenyl)-butan-1-one 
• 83072-21-3 4-(4-chloro-benzyl)-piperidin-4-ol 

Relevant articles and documents

INDOLE DERIVATIVE AND USE FOR TREATMENT OF CANCER

The present invention relates to a compound represented by the formula (I’) wherein A is a benzene ring optionally having substituents, R1, R2a and R3 are each a hydrogen atom, a hydrocarbon group optionally having substituents or a heterocyclic group optionally having substituents, R1 and R2a may form a ring via X, when R1 and R2a form a ring via X, R1 and R2a are each a bond or a divalent C1-5 acyclic hydrocarbon group optionally having substituents, and X is a bond, an oxygen atom, an optionally oxidized sulfur atom or an imino group optionally having a substituent, provided that R1, R2a and X are not bonds at the same time, or a salt thereof, and an agent for inhibiting kinase (phosphorylation enzyme), which contains this compound or a prodrug thereof. The compound of the present invention has an inhibitory activity against kinase such as a vascular endothelial growth factor receptor (VEGFR) and the like, and is useful as an agent for the prophylaxis or threatment of cancer and the like.