871129-50-9Relevant academic research and scientific papers
An Efficient Synthesis of Enantiopure (2 R,3 R)-β-Methoxytyrosine
Fan, Shi-Ming,Tian, Xia,Yang, Yi-Hua,Jin, Long Yi,Liu, Shou-Xin
, p. 2553 - 2556 (2015)
Enantiopure (2R,3R)-β-methoxytyrosine was stereoselectively synthesized from ethyl 3-(4-hydroxyphenyl)-3-oxopropanoate protected by 2-methoxyethoxymethyl (MEM) (ee >98%). l-Aminoacylase-catalyzed resolution of the corresponding erythro-N-acetyl derivatives afforded (2S,3S)-(4-MEM)-β-methoxytyrosine (ee >99%). The conversion increased to 98% by optimizing the synthesis to yield enantiopure N-acetyl-(2R,3R)-(4-MEM)-methoxytyrosine. N-Acyl cleavage was accomplished under mild conditions.
Synthesis and herbicidal evaluation of novel 3-[(α-hydroxy- substituted)benzylidene]pyrrolidine-2,4-diones
Zhu, Youquan,Zou, Xiaomao,Hu, Fangzhong,Yao, Changsheng,Liu, Bin,Yang, Huazheng
, p. 9566 - 9570 (2007/10/03)
A series of 3-[(α-hydroxy-substituted) benzylidene]pyrrolidine-2,4- dione derivatives were synthesized as candidate herbicides by reacting different aroyl acetates with N-substituted glycine esters. The new compounds were identified by 1H NMR spectroscopy and elemental analyses. Their herbicidal activities were evaluated. Some compounds exhibited excellent herbicidal activities at a dose of 187.5 g/ha. A suitable electron-donating substituent at the 2- and/or 4-position of the phenyl ring was essential for high herbicidal activity, a result that has not been reported before. It was also found that the title compound's structure-activity relationships were different from those of other similar kinds of earlier compounds, a result that may depend on the enol structure difference.
