871261-02-8

Basic information

• Product Name: 2-oxo-2-(tetrahydro-2H-pyran-4-yl)acetic acid
• Synonyms: 2-oxo-2-(tetrahydro-2H-pyran-4-yl)acetic acid
• CAS NO: 871261-02-8
• Molecular Weight: 158.154
• Mol File: 871261-02-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-oxo-2-(tetrahydro-2H-pyran-4-yl)acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-oxo-2-(tetrahydro-2H-pyran-4-yl)acetic acid(871261-02-8)
• EPA Substance Registry System: 2-oxo-2-(tetrahydro-2H-pyran-4-yl)acetic acid(871261-02-8)

Safety Data

• Hazardous Substances Data: 871261-02-8(Hazardous Substances Data)

Upstream product

• 5337-03-1 tetrahydro-2H-pyran-4-carboxylic acid 
• 1619901-30-2 C₁₅H₂₈O₄Si 
• 29943-42-8 Tetrahydro-4H-pyran-4-one 
• 861160-58-9 C₉H₁₄O₄ 

Downstream Products

• 811842-25-8 (S)-2-amino-2-(tetrahydro-2 H-pyran-4-yl)acetic acid 
• 871261-03-9 C₁₄H₁₆FNO₅S 

Relevant articles and documents

SYNTHESIS METHOD FOR L-CYCLIC ALKYL AMINO ACID AND PHARMACEUTICAL COMPOSITION HAVING THEREOF

A synthesis method for L-cyclic alkyl amino acid and a pharmaceutical composition having the said amino acid are provide in the present disclosure provides. The synthesis method comprises: step A.) preparing a cyclic alkyl keto acid or a cyclic alkyl keto acid salt having Structural Formula (I) or Structural Formula (II), and step B.) mixing the cyclic alkyl keto acid or the cyclic alkyl keto acid salt with ammonium formate, a leucine dehydrogenase, a formate dehydrogenase and a coenzyme NAD+, and carrying out a reductive amination reaction to generate the L-cyclic alkyl amino acid, wherein the Structural Formula (I) is where n1≧1, m1≧0 and the M1 is H or a monovalent cation; the Structural Formula (II) is where n2≧0, m2≧0, the M2 is H or a monovalent cation, an amino acid sequence of the leucine dehydrogenase is SEQ ID No.1.

Non-steroidal progesterone receptor modulators

The present invention relates to non-steroidal progesterone receptor modulators of the general formula I, the use of the progesterone receptor modulators for the manufacture of medicaments, and pharmaceutical compositions which comprise these compounds. The compounds according to the invention are suitable for the therapy and prophylaxis of gynecological disorders such as endometriosis, leiomyomas of the uterus, dysfunctional bleeding and dysmenorrhoea, and for the therapy and prophylaxis of hormone-dependent tumours and for use for female fertility control and for hormone replacement therapy.