871261-06-2Relevant academic research and scientific papers
PROCESS FOR MAKING N-SULFONATED-AMINO ACID DERIVATIVES
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Page/Page column 23, (2008/06/13)
This invention relates to a process for preparing optically active α -amino acid substrates which are used to make potent lethal factor (LF) inhibitors for the treatment of anthrax. This invention further relates to a process for synthesis of potent LF-inhibitors for the treatment of anthrax. Specifically, the invention concerns a novel, high-yielding and highly enantioselective asymmetric hydrogenation reaction of a tetrasubstituted ene-sulfonamide acid or ester.
