87128-27-6

Usage

Uses

Used in Pharmaceutical Industry:
Benzamide, 4-(hydroxymethyl)(9CI) is utilized as an intermediate in the synthesis of other organic compounds, particularly in the development of pharmaceuticals. Its specific structure and chemical environment may confer biological activities that are valuable in drug discovery and development processes.
Used in Agrochemical Industry:
In the agrochemical sector, Benzamide, 4-(hydroxymethyl)(9CI) may serve as a precursor for the creation of compounds with pesticidal or herbicidal properties, contributing to the development of more effective and targeted agrochemicals.
Used in Materials Science:
Benzamide, 4-(hydroxymethyl)(9CI) also finds potential applications in materials science, where it could be employed in the design and synthesis of new materials with specific properties, such as polymers or other advanced materials with tailored characteristics for various industrial uses.

Upstream product

• 874-86-2 4-cyanobenzyl chloride 
• 619-56-7 4-chlorobenzamide 
• 105-07-7 4-cyanobenzaldehyde 
• 6051-41-8 4-formylbenzamide 
• 619-55-6 para-methylbenzamide 

Downstream Products

• 874-89-5 4-Cyanobenzyl alcohol 

Relevant academic research and scientific papers

The Stereoselective Oxidation of para-Substituted Benzenes by a Cytochrome P450 Biocatalyst

The serine 244 to aspartate (S244D) variant of the cytochrome P450 enzyme CYP199A4 was used to expand its substrate range beyond benzoic acids. Substrates, in which the carboxylate group of the benzoic acid moiety is replaced were oxidised with high activity by the S244D mutant (product formation rates >60 nmol.(nmol-CYP)?1.min?1) and with total turnover numbers of up to 20,000. Ethyl α-hydroxylation was more rapid than methyl oxidation, styrene epoxidation and S-oxidation. The S244D mutant catalysed the ethyl hydroxylation, epoxidation and sulfoxidation reactions with an excess of one stereoisomer (in some instances up to >98 %). The crystal structure of 4-methoxybenzoic acid-bound CYP199A4 S244D showed that the active site architecture and the substrate orientation were similar to that of the WT enzyme. Overall, this work demonstrates that CYP199A4 can catalyse the stereoselective hydroxylation, epoxidation or sulfoxidation of substituted benzene substrates under mild conditions resulting in more sustainable transformations using this heme monooxygenase enzyme.

Combined catalytic system of scandium triflate and boronic ester for amide bond cleavage

We have found that the combination of scandium with boronic ester enables the cleavage of amide bonds. Primary amides were converted to the corresponding esters in the presence of catalytic amounts of scandium triflate and boronic ester under mild and neutral conditions. This unique catalytic system can be applied to the deprotection of acetylaniline derivatives. In addition, control NMR experiments were carried out to examine the effect of the boronic esters. Copyright

Palladium-catalyzed direct hydroxymethylation of aryl halides and triflates with potassium acetoxymethyltrifluoroborate

Suzuki-Miyaura cross-coupling reactions of aryl halides and triflates with potassium acetoxymethyltrifluoroborate afforded the corresponding aryl and heteroaryl methanol products in moderate to excellent yields.