871311-22-7Relevant articles and documents
Synthesis of a small library of bivalent α-d-mannopyranosides for lectin cross-linking
Bergeron-Brlek, Milan,Shiao, Tze Chieh,Trono, M. Corazon,Roy, René
, p. 1479 - 1489 (2011)
A small library of bivalent α-d-mannopyranosides having rigid linkers was constructed in order to evaluate the effects of inter-saccharide distances upon multivalent binding interactions with plant and bacterial lectins. To this end, iodoaryl and propargyl α-d-mannopyranosides were synthesized and the former treated with TMS-acetylene under palladium chemistry to provide their corresponding ethynylaryl derivatives. A library of 15 dimeric members was then obtained using Lewis acid catalyzed glycosidation, aryl-aryl homocoupling, transition metal catalyzed Sonogashira cross-coupling reactions, and oxidative Glaser homocoupling.