871345-34-5Relevant academic research and scientific papers
Simultaneous dual protein labeling using a triorthogonal reagent
Rashidian, Mohammad,Kumarapperuma, Sidath C.,Gabrielse, Kari,Fegan, Adrian,Wagner, Carston R.,Distefano, Mark D.
, p. 16388 - 16396 (2013)
Construction of heterofunctional proteins is a rapidly emerging area of biotherapeutics. Combining a protein with other moieties, such as a targeting element, a toxic protein or small molecule, and a fluorophore or polyethylene glycol (PEG) group, can imp
TRIORTHOGONAL REAGENTS FOR DUAL PROTEIN CONJUGATION
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Page/Page column 26, (2015/05/05)
The present invention relates to triorthogonal reagents useful for site-specifically modifying a protein with two orthogonal groups that can be subsequently functionalized in a single one-pot procedure. This approach relies on the selective tagging of pro
Selective and orally bioavailable phenylglycine tissue factor/factor VIIa inhibitors
Zbinden, Katrin Groebke,Obst-Sander, Ulrike,Hilpert, Kurt,Kuehne, Holger,Banner, David W.,Boehm, Hans-Joachim,Stahl, Martin,Ackermann, Jean,Alig, Leo,Weber, Lutz,Wessel, Hans Peter,Riederer, Markus A.,Tschopp, Thomas B.,Lave, Thierry
, p. 5344 - 5352 (2007/10/03)
We describe the structure-based design and synthesis of highly potent, orally bioavailable tissue factor/factor VIIa inhibitors which interfere with the coagulation cascade by selective inhibition of the extrinsic pathway.
