871365-72-9Relevant academic research and scientific papers
A concise synthesis of 1,4-dihydro-[1,4]diazepine-5,7-dione, a novel 7-TM receptor ligand core structure with melanocortin receptor agonist activity
Szewczyk, Jerzy R.,Laudeman, Chris P.,Sammond, Doug M.,Villeneuve, Manon,Minick, Douglas J.,Grizzle, Mary K.,Daniels, Alejandro J.,Andrews, John L.,Ignar, Diane M.
experimental part, p. 1822 - 1833 (2010/05/02)
Finding small non-peptide molecules for G protein-coupled receptors (GPCR) whose endogenous ligands are peptides, is a very important task for medicinal chemists. Over the years, compounds mimicking peptide structures have been discovered, and scaffolds e
NOVEL DIAZEPINE COMPOUNDS AS LIGANDS OF THE MELANOCORTIN 1 AND/OR 4 RECEPTORS
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Page/Page column 36, (2010/02/15)
There is provided novel diazepines that function as agonists at the melanocortin 4 receptor and as agonists at the melanocortin 1 receptor, pharmaceutical compositions containing them, methods for their use in treatment, and processes for their preparatio
