87145-34-4Relevant academic research and scientific papers
A model for Zn(II)-containing-β-lactamase: Synthesis, X-ray crystal structure of a Zinc(II) complex bearing thiol group and hydrolysis of phosphate diester
Kurosaki, Hiromasa,Tawada, Toshiaki,Kawasoe, Satomi,Ohashi, Yoko,Goto, Masafumi
, p. 1333 - 1337 (2000)
A novel N3S1 typed tripodal ligand bearing an SH group, N-(mercaptoethyl)-di(2-pyridylmethyl)amine, DPASH, was prepared and its zinc(II) complex, [Zn(II)(DPAS)Cl], was structurally characterized by X-ray crystallography. [Zn(II)(DPAS)Cl] promoted hydrolysis of sodium bis(p-nitrophenyl)hydrogenphosphate), BNP-. (C) 2000 Elsevier Science Ltd. All rights reserved.
Live-Cell Pyrophosphate Imaging by in Situ Hot-Spot Generation
Li, Mingmin,Li, Jin,Di, Huixia,Liu, Huiqiao,Liu, Dingbin
, p. 3532 - 3537 (2017)
Controlling the electromagnetic hot-spot generation is essential for surface-enhanced Raman scattering (SERS) assays. Current hot-spot-based SERS assays have been extensively studied in solutions or on substrates. However, probing biospecies by controlling the hot-spot assembly in living systems has not been demonstrated thus far. Herein, we report a background-free SERS probe for imaging pyrophosphate (PPi), a biochemically significant anion, in living cells. Intracellular PPi is able to induce the nanoparticle dimerization, thus creating an intense electromagnetic hot spot and dramatically enhancing the signal of the Raman reporters residing in the hot spot. More impressively, the reporter we used in this study provides a strong and sharp single peak in the cellular Raman-silent region (1800-2800 cm-1), thus eliminating the possible background interference. This strategy could be readily extended to detect other biomarkers by only replacing the recognition ligands. (Figure Presented).
Metal beta-lactamase inhibitor as well as preparation method and application thereof
-
Paragraph 0048; 0051, (2020/10/14)
The invention discloses a metal beta-lactamase inhibitor as well as a preparation method and application thereof. The preparation method comprises the following steps: dissolving a pyridylamine compound in a solvent 1, adding an ester compound and carbonate, stirring at 80-100 DEG C for 11-13 hours, cooling the reaction product to room temperature, extracting, carrying out vacuum drying, and purifying to obtain a product 1; dissolving the product 1 in a solvent 2, adding ester-based hydrolysate, stirring for 1.5-2.5 hours at room temperature, and extracting, vacuum-drying and purifying a reaction product to obtain a Zn chelating agent; dissolving a beta-lactamase compound in a solvent 3, adding a Zn chelating agent and an alkali, stirring for 11-13 hours at room temperature, and extracting, vacuum-drying and purifying a reaction product to obtain the metal beta-lactamase inhibitor which can be used as a combined agent of antibiotics for inhibiting bacterial proliferation. The inhibitor is simpler to prepare and low in material cost, reduces the biotoxicity of molecules, and has higher antibacterial efficiency.
A mercury(II) ion sensor device based on an organic field effect transistor with an extended-gate modified by dipicolylamine
Minami, Tsuyoshi,Sasaki, Yui,Minamiki, Tsukuru,Koutnik, Petr,Anzenbacher, Pavel,Tokito, Shizuo
supporting information, p. 17666 - 17668 (2015/12/18)
Herein, we report an organic field effect transistor (OFET) with an extended-gate modified by an artificial receptor for the detection of mercury(ii) ions (Hg2+) in water. The sensor device is easy to fabricate, reusable, disposable, and portable. Thus OFET sensors could be applied for low-cost on-site detection of Hg2+.
