87151-27-7Relevant academic research and scientific papers
(E)-Methyl 2-anilinomethyl-ene-3-oxo-butanoate: X-ray and density functional theory studies
Langer, Vratislav,Scholtzova, Eva,Milata, Viktor,Solcan, Tomas
, p. o552-o554 (2007)
Mol-ecules of the title compound, C12H13NO3, are not planar and are stabilized by electrostatic inter-actions, as the dipole moment of the mol-ecule is 3.76 D. They are also stabilized by intra-molecular hydrogen bonds of N...O and C...O types, and by a complicated network of weak inter-molecular hydrogen bonds of the C...O type. This paper also reports the theoretical investigation of the hydrogen bonding and electronic structure of the title compound using natural bond orbital (NBO) analysis. International Union of Crystallography 2007.
An Efficient and Highly Diastereoselective Synthesis of GSK1265744, a Potent HIV Integrase Inhibitor
Wang, Huan,Kowalski, Matthew D.,Lakdawala, Ami S.,Vogt, Frederick G.,Wu, Lianming
supporting information, p. 564 - 567 (2015/03/04)
A novel synthesis of GSK1265744, a potent HIV integrase inhibitor, is described. The synthesis is highlighted by an efficient construction of the densely functionalized pyridinone core as well as a highly diastereoselective formation of the acyl oxazolidine moiety. The latter exploits the target molecules ability to chelate to Mg2+, a key feature in the integrase inhibitors mechanism of action.
