871575-41-6

Upstream product

• 871575-31-4 methyl 2-(2,2-dichloropropionylamino)-3-(1H-indol-3-yl)propionate 
• 871575-32-5 methyl 7-methylene-6-oxo-1,3,4,5,6,7-hexahydro-azocino[4,5,6-cd]indole-4-carboxylate 
• 871575-40-5 1,5-di-tert-butyl 4-methyl 7-methylene-6-oxo-3,4,6,7-tetrahydro-azocino[4,5,6-cd]indole-1,4,5-tricarboxylate 

Relevant academic research and scientific papers

Dragmacidin E synthesis studies. Preparation of a model cycloheptannelated indole fragment

(Chemical Equation Presented) The conversion of N-2,2-dichloropropionyl indole methyl ester into a tetracyclic cycloheptannelated indole model compound for the synthesis of dragmacidin E was accomplished in 10 steps. Key reactions include a Witkop cyclization to fashion a C-C bond at C(4) of the indole nucleus and a subsequent Dieckmann cyclization to deliver the desired cycloheptanoid ring.