871658-02-5 Usage
Uses
Used in Organic Synthesis:
2-Azabicyclo[2.1.1]hexane hydrochloride is used as a catalyst in various organic synthesis processes. Its unique bicyclic structure and nitrogen atom enable it to facilitate numerous chemical reactions, making it a valuable component in the synthesis of a wide range of organic compounds.
Used in Pharmaceutical and Agrochemical Production:
As a building block, 2-Azabicyclo[2.1.1]hexane hydrochloride is utilized in the production of pharmaceuticals and agrochemicals. Its ability to influence the stereochemistry of reactions allows for the creation of chiral compounds, which are essential in the development of various drugs and agrochemicals.
Used in Chiral Compound Preparation:
2-Azabicyclo[2.1.1]hexane hydrochloride is used as a key component in the preparation of chiral compounds, particularly in the synthesis of certain drugs. Its influence on the stereochemistry of reactions enables the production of enantiomerically pure compounds, which are crucial for the development of effective and safe medications.
Used in Antidepressant and Anticholinergic Research:
2-Azabicyclo[2.1.1]hexchloride has been studied for its potential anticholinergic and antidepressant properties. Its unique chemical structure and interactions with biological systems make it a promising candidate for further research and development in the field of mental health and neurological disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 871658-02-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,1,6,5 and 8 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 871658-02:
(8*8)+(7*7)+(6*1)+(5*6)+(4*5)+(3*8)+(2*0)+(1*2)=195
195 % 10 = 5
So 871658-02-5 is a valid CAS Registry Number.
871658-02-5Relevant academic research and scientific papers
Preparation of 2-Azabicyclo[21.1]hexane Hydrochloride
Liao, Haili,Li, Aimin,Chen, Xingsong,Liang, Kun,Shen, Yang,Liang, Qingfeng,Xu, Kewei,Shore, Daniel G. M.,Villemure, Elisia,Siu, Michael,Huestis, Malcolm P.
supporting information, p. 2251 - 2253 (2016/11/14)
A batchwise, multigram preparation of 2-azabicyclo-[2.1.1]hexane hydrochloride (1·HCl) was developed, delivering a total of 195 grams of material. The key synthetic step involves an intramolecular displacement of a primary alkyl chloride with a tert-butylsulfinamide to forge the [2.1.1]-bicyclic ring system.
HETROARYL BENZAMIDE DERIVATIVES FOR USE AS GLK ACTIVATORS IN THE TREATMENT OF DIABETES
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Page/Page column 185, (2008/06/13)
Compounds of Formula (I) wherein: R1 is hydroxymethyl; R2 is selected from -C(O)NR4R5, SO2NR4R5, S(O)pR4 and HET-2; HET-1 is a 5- or 6-membered, optionally substituted C-linked heteroaryl ring; HET-2 is a 4-, 5- or 6-membered, C- or N-linked optionally substituted heterocyclyl ring; R3 is selected from halo, fluoromethyl, difluoromethyl, trifluoromethyl, methyl, methoxy and cyano; R4 is selected from for example hydrogen, optionally substituted (1-4C)alkyl and HET-2; R5 is hydrogen or (1-4C)alkyl; or R4 and R5 together with the nitrogen atom to which they are attached may form a heterocyclyl ring system as defined by HET-3; HET-3 is for example an optionally substituted N-linked, 4, 5 or 6 membered, saturated or partially unsaturated heterocyclyl ring; p is (independently at each occurrence) 0, 1 or 2; m is 0 or 1; n is 0, 1 or 2; provided that when m is 0, then n is 1 or 2; or a salt, pro drug or solvate thereof, are described. Their use as GLK activators, pharmaceutical compositions containing them, and processes for their preparation are also described.
