871691-20-2Relevant academic research and scientific papers
Synthesis, structure-activity relationships, and biological studies of chromenochalcones as potential antileishmanial agents
Gupta, Suman,Shivahare, Rahul,Korthikunta, Venkateswarlu,Chandasana, Hardik,Suthar, Manish K.,Agnihotri, Pragati,Vishwakarma, Preeti,Chaitanya, Telaprolu K.,Kancharla, Papireddy,Khaliq, Tanvir,Gupta, Shweta,Bhatta, Rabi Sankar,Pratap, J. Venkatesh,Saxena, Jitendra K.,Tadigoppula, Narender
, p. 3342 - 3357 (2014/05/20)
Antileishmanial activities of a library of synthetic chalcone analogues have been examined. Among them, five compounds (11, 14, 16, 17, 22, and 24) exhibited better activity than the marketed drug miltefosine in in vitro studies against the intracellular amastigotes form of Leishmania donovani. Three promising compounds, 16, 17, and 22, were tested in a L. donovani/hamster model. Oral administration of chalcone 16, at a concentration of 100 mg/kg of body weight per day for 5 consecutive days, resulted in >84% parasite inhibition at day 7 post-treatment and it retained the activity until day 28. The molecular and immunological studies revealed that compound 16 has a dual nature to act as a direct parasite killing agent and as a host immunostimulant. Pharmacokinetics and serum albumin binding studies also suggest that compound 16 has the potential to be a candidate for the treatment of the nonhealing form of leishmaniasis.
Synthesis and insight into the structure-activity relationships of chalcones as antimalarial agents
Tadigoppula, Narender,Korthikunta, Venkateswarlu,Gupta, Shweta,Kancharla, Papireddy,Khaliq, Tanvir,Soni, Awakash,Srivastava, Rajeev Kumar,Srivastava, Kumkum,Puri, Sunil Kumar,Raju, Kanumuri Siva Rama,Wahajuddin,Sijwali, Puran Singh,Kumar, Vikash,Mohammad, Imran Siddiqi
, p. 31 - 45 (2013/02/25)
Licochalcone A (I), isolated from the roots of Chinese licorice, is the most promising antimalarial compound reported so far. In continuation of our drug discovery program, we isolated two similar chalcones, medicagenin (II) and munchiwarin (III), from Crotalaria medicagenia, which exhibited antimalarial activity against Plasmodium falciparum. A library of 88 chalcones were synthesized and evaluated for their in vitro antimalarial activity. Among these, 67, 68, 74, 77, and 78 exhibited good in vitro antimalarial activity against P. falciparum strains 3D7 and K1 with low cytotoxicity. These chalcones also showed reduction in parasitemia and increased survival time of Swiss mice infected with Plasmodium yoelii (strain N-67). Pharmacokinetic studies indicated that low oral bioavailability due to poor ADME properties. Molecular docking studies revealed the binding orientation of these inhibitors in active sites of falcipain-2 (FP-2) enzyme. Compounds 67, 68, and 78 showed modest inhibitory activity against the major hemoglobin degrading cysteine protease FP-2.
