87170-22-7

Basic information

• Product Name: 3-CHLORO-4-(1-NAPHTHYLOXY)ANILINE HYDROCHLORIDE
• Synonyms: 3-CHLORO-4-(1-NAPHTHYLOXY)ANILINE HYDROCHLORIDE
• CAS NO: 87170-22-7
• Molecular Formula: C16H13Cl2NO
• Molecular Weight: 306.18652
• Mol File: 87170-22-7.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-CHLORO-4-(1-NAPHTHYLOXY)ANILINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-4-(1-NAPHTHYLOXY)ANILINE HYDROCHLORIDE(87170-22-7)
• EPA Substance Registry System: 3-CHLORO-4-(1-NAPHTHYLOXY)ANILINE HYDROCHLORIDE(87170-22-7)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 87170-22-7(Hazardous Substances Data)

Upstream product

• 76590-07-3 1-(2-chloro-4-nitrophenoxy)naphthalene 

Relevant articles and documents

Discovery of a Novel Class of ERRα Agonists

A novel class of estrogen-related receptor α (ERRα) agonists has been discovered. A structure-activity relationship study of high-throughput screening hits 1 and 2 led to the discovery of benzimidazole 3d (DS20362725) and acetophenone analogue 5c (DS45500853). The X-ray crystal structure of the ERRα ligand-binding domain in complex with 5c and PGC-1α coactivator peptide revealed conformational changes in the ligand-binding pocket to accommodate 5c and the key interaction between the protein and ligand. Since both analogues avoided PPARγtranscriptional activity, they can be useful tool compounds for investigating biological ERRα functions.