871708-43-9Relevant academic research and scientific papers
Identification of pyrazolopyridine derivatives as novel spleen tyrosine kinase inhibitors
Huang, Yahui,Li, Yu,Dong, Guoqiang,Zhang, Wannian,Liu, Na,Sheng, Chunquan
, (2018)
Inhibition of spleen tyrosine kinase (Syk) is a promising strategy for the treatment of various allergic and autoimmune disorders such as asthma, rheumatoid arthritis, and allergic rhinitis. Previously, a Syk inhibitor with novel indazole scaffold was discovered by structure-based virtual screening. Herein, the structure–activity relationship of the indazole Syk inhibitors was investigated. Several new inhibitors demonstrated potent activity against Syk. In particular, compound 18c showed good Syk inhibitory activity (IC50 = 1.2 μM), representing a good lead compound for further optimization.
3-AMINOINDAZOLES
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Page/Page column 73, (2008/06/13)
Novel 3-aminoindazoles of formula (I) are SGK-inhibitors and can be used for treating SGK-related diseases and illnesses such as diabetes, obesity, metabolic syndrome (dyslipidaemia), systemic and pulmonary hypertonia, cardiovascular diseases and renal diseases, and generally any type of fibroses and inflammatory processes.
