871738-91-9

Upstream product

• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 17123-68-1 4,4-dimethylhept-6-en-2-one 
• 871739-01-4 2-(4-methoxy-phenyl)-4,4-dimethyl-hept-6-en-2-ol 
• 871738-90-8 2-(4-methoxy-phenyl)-2,4,4-trimethyl-tetrahydro-pyran 

Relevant academic research and scientific papers

Room temperature intramolecular hydro-O-alkylation of aldehydes: sp 3 C-H functionalization via a lewis acid catalyzed tandem 1,5-hydride transfer/cyclization

(Chemical Equation Presented) The scope and limitations of intramolecular hydro-O-alkylation of aldehyde substrates leading to spiroketals and bicyclic ketals and aminals is reported. The direct transformation of tertiary and sterically hindered secondary sp3 C-H bonds into C-O bonds under the action of a catalytic amount of a variety of Lewis acids is described. The mechanism of these transformations is proposed to involve a tandem hydride transfer/cyclization sequence.

Room temperature hydroalkylation of electron-deficient olefins: sp 3 C-H functionalization via a Lewis acid-catalyzed intramolecular redox event

A practical method for the intramolecular hydroalkylation of electron-deficient olefins has been developed. The direct transformation of benzylic, tertiary, and sterically hindered secondary sp3 C-H bonds into C-C bonds under the action of a catalytic amount of a variety of Lewis acids is described. The mechanism of these transformations is proposed to involve a tandem hydride transfer/cyclization sequence. Copyright