87174-83-2

Upstream product

• 87174-89-8 dimethyl N-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-L-α-aminosuberate 
• 19641-64-6 N-(benzyloxycarbonyl)-L-α-aminosuberic acid 
• 19741-14-1 4-[(2,4-diaminopteridin-6-ylmethyl)methylamino]benzoic acid 
• 98062-58-9 (S)-2-Benzyloxycarbonylamino-octanedioic acid dimethyl ester 
• 87206-10-8 dimethyl L-α-aminosuberate 

Relevant academic research and scientific papers

Methotrexate analogues. 20. Replacement of glutamate by longer-chain amino diacids: Effects on dihydrofolate reductase inhibition, cytotoxicity, and in vivo antitumor activity

Chain-extended analogues of methotrexate were synthesized by condensation of 4-amino-4-deoxy-N10-methylpteroic acid with esters of L-α-aminoadipic, L-α-aminopimelic, and L-α-aminosuberic acids, followed by ester hydrolysis with acid or base. Co