871801-40-0Relevant academic research and scientific papers
Cobalt-mediated [3 + 2]-annulation reaction of alkenes with α,β-unsaturated ketones and imines
Schomaker, Jennifer M.,Toste, F. Dean,Bergman, Robert G.
, p. 3698 - 3700 (2009)
Image Presented The utility of cobalt dinitrosyl complexes for the [3 + 2] annulation of alkenes with unsaturated enones and ketimines has been demonstrated. Reaction of a series of cobalt dinitrosyl/alkene adducts with conjugate acceptors in the presence of Sc(OTf)3/LHMDS formed two new C-C bonds at the carbons α to the nitrosyl groups of the substrate, leading to unusual tri- and tetracycles. Retrocycloaddition of these products in the presence of norbornadiene yielded functionalized tetrasubstituted bicyclic olefins.
